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elemental microchemical analysis  (SPECTRO Analytical)
90
SPECTRO Analytical elemental microchemical analysis
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fmoc r 3 amino 3  (Chem Impex International)
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Chem Impex International fmoc r 3 amino 3
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oxymapure  (Chem Impex International)
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Chem Impex International oxymapure
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glycerol  (Chem Impex International)
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Chem Impex International glycerol
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Shimadzu Corporation esi lc ms2
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vidas b.r.a.h.m.s pct analyzer  (bioMerieux gmbh)
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9hfluoren 9 yl methoxyformamido 2 4 dimethoxybenzyl phenoxyacetic acid fmoc rink amide linker  (Chem Impex International)
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p propargyloxyl l phenylalanine  (Chem Impex International)
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Chem Impex International p propargyloxyl l phenylalanine
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emission 39  (Chem Impex International)
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Chem Impex International emission 39
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drugs cebranopadol  (MedChemExpress)
99
MedChemExpress drugs cebranopadol
(A) Escalation of cocaine self-administration after 15 (6 hours) sessions. **P < 0.01, ***P < 0.001, significantly different from day 1. (B) Effect of <t>cebranopadol</t> on cocaine self-administration. The data are expressed as the mean ± S.E.M. number of responses on the active lever (A) and inactive lever (B); n = 14. ###P < 0.001, significantly different from Baseline. **P < 0.01, ***P < 0.001, significantly different from vehicle-treated rats (0.0 μg/kg). $$P < 0.01, 50 μg/kg versus 25 μg/kg. (C) Hourly time course of infusions.
Drugs Cebranopadol, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ptr-ms viewer version 3.0.0.101  (IONICON Inc)
90
IONICON Inc ptr-ms viewer version 3.0.0.101
(A) Escalation of cocaine self-administration after 15 (6 hours) sessions. **P < 0.01, ***P < 0.001, significantly different from day 1. (B) Effect of <t>cebranopadol</t> on cocaine self-administration. The data are expressed as the mean ± S.E.M. number of responses on the active lever (A) and inactive lever (B); n = 14. ###P < 0.001, significantly different from Baseline. **P < 0.01, ***P < 0.001, significantly different from vehicle-treated rats (0.0 μg/kg). $$P < 0.01, 50 μg/kg versus 25 μg/kg. (C) Hourly time course of infusions.
Ptr Ms Viewer Version 3.0.0.101, supplied by IONICON Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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full automatic hematology analyzer bc-2800vet  (MAIRUI INTERNATIONAL CO LTD)
90
MAIRUI INTERNATIONAL CO LTD full automatic hematology analyzer bc-2800vet
(A) Escalation of cocaine self-administration after 15 (6 hours) sessions. **P < 0.01, ***P < 0.001, significantly different from day 1. (B) Effect of <t>cebranopadol</t> on cocaine self-administration. The data are expressed as the mean ± S.E.M. number of responses on the active lever (A) and inactive lever (B); n = 14. ###P < 0.001, significantly different from Baseline. **P < 0.01, ***P < 0.001, significantly different from vehicle-treated rats (0.0 μg/kg). $$P < 0.01, 50 μg/kg versus 25 μg/kg. (C) Hourly time course of infusions.
Full Automatic Hematology Analyzer Bc 2800vet, supplied by MAIRUI INTERNATIONAL CO LTD, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


(A) Escalation of cocaine self-administration after 15 (6 hours) sessions. **P < 0.01, ***P < 0.001, significantly different from day 1. (B) Effect of cebranopadol on cocaine self-administration. The data are expressed as the mean ± S.E.M. number of responses on the active lever (A) and inactive lever (B); n = 14. ###P < 0.001, significantly different from Baseline. **P < 0.01, ***P < 0.001, significantly different from vehicle-treated rats (0.0 μg/kg). $$P < 0.01, 50 μg/kg versus 25 μg/kg. (C) Hourly time course of infusions.

Journal: The Journal of Pharmacology and Experimental Therapeutics

Article Title: Cebranopadol Blocks the Escalation of Cocaine Intake and Conditioned Reinstatement of Cocaine Seeking in Rats

doi: 10.1124/jpet.117.241042

Figure Lengend Snippet: (A) Escalation of cocaine self-administration after 15 (6 hours) sessions. **P < 0.01, ***P < 0.001, significantly different from day 1. (B) Effect of cebranopadol on cocaine self-administration. The data are expressed as the mean ± S.E.M. number of responses on the active lever (A) and inactive lever (B); n = 14. ###P < 0.001, significantly different from Baseline. **P < 0.01, ***P < 0.001, significantly different from vehicle-treated rats (0.0 μg/kg). $$P < 0.01, 50 μg/kg versus 25 μg/kg. (C) Hourly time course of infusions.

Article Snippet: Drugs Cebranopadol (Med Chem Express, Monmouth Junction, NJ) was dissolved in vehicle that consisted of 5% dimethylsulfoxide, 5% Emulphor (Solvay, Bruxelles, Belgium), and 90% distilled water.

Techniques:

Effect of cebranopadol on SCM self-administration after 1 hour (A) or 6 hours (B). The data are expressed as the mean ± S.E.M. number of rewards; n = 12.

Journal: The Journal of Pharmacology and Experimental Therapeutics

Article Title: Cebranopadol Blocks the Escalation of Cocaine Intake and Conditioned Reinstatement of Cocaine Seeking in Rats

doi: 10.1124/jpet.117.241042

Figure Lengend Snippet: Effect of cebranopadol on SCM self-administration after 1 hour (A) or 6 hours (B). The data are expressed as the mean ± S.E.M. number of rewards; n = 12.

Article Snippet: Drugs Cebranopadol (Med Chem Express, Monmouth Junction, NJ) was dissolved in vehicle that consisted of 5% dimethylsulfoxide, 5% Emulphor (Solvay, Bruxelles, Belgium), and 90% distilled water.

Techniques:

(A) Average total distance traveled (in meters) during the four sessions of CPP conditioning after oral injection of cebranopadol or vehicle. (B) Cebranopadol-induced conditioned place preference. The data are expressed as the time spent in the drug-paired chamber; n = 9, **P < 0.01 versus Pretest.

Journal: The Journal of Pharmacology and Experimental Therapeutics

Article Title: Cebranopadol Blocks the Escalation of Cocaine Intake and Conditioned Reinstatement of Cocaine Seeking in Rats

doi: 10.1124/jpet.117.241042

Figure Lengend Snippet: (A) Average total distance traveled (in meters) during the four sessions of CPP conditioning after oral injection of cebranopadol or vehicle. (B) Cebranopadol-induced conditioned place preference. The data are expressed as the time spent in the drug-paired chamber; n = 9, **P < 0.01 versus Pretest.

Article Snippet: Drugs Cebranopadol (Med Chem Express, Monmouth Junction, NJ) was dissolved in vehicle that consisted of 5% dimethylsulfoxide, 5% Emulphor (Solvay, Bruxelles, Belgium), and 90% distilled water.

Techniques: Injection, Conditioned Place Preference

Effect of cebranopadol on the conditioned reinstatement of cocaine seeking. During the self-administration training phase, the rats learned to press the lever for cocaine in the presence of a contextual/discriminative stimulus (SD). During extinction (Ext), lever responding progressively decreased. Twenty-four hours after the last extinction session, all of the rats were presented with a neutral stimulus (SN), and the number of responses on the previous cocaine-paired lever was not reinstated. In the reinstatement test, responses to the cocaine-paired cues increased in the presence of the SD. Cebranopadol at the dose of 50 μg/kg significantly reduced relapse that was elicited by presentation of the SD. The data are expressed as the mean ± S.E.M. number of responses on the cocaine active lever (A) and inactive lever (B); n = 10. ##P < 0.01, significantly different from extinction; ***P < 0.01, significantly different from vehicle-treated rats (0.0 μg/kg); $P < 0.05, significantly different from 25 μg/kg.

Journal: The Journal of Pharmacology and Experimental Therapeutics

Article Title: Cebranopadol Blocks the Escalation of Cocaine Intake and Conditioned Reinstatement of Cocaine Seeking in Rats

doi: 10.1124/jpet.117.241042

Figure Lengend Snippet: Effect of cebranopadol on the conditioned reinstatement of cocaine seeking. During the self-administration training phase, the rats learned to press the lever for cocaine in the presence of a contextual/discriminative stimulus (SD). During extinction (Ext), lever responding progressively decreased. Twenty-four hours after the last extinction session, all of the rats were presented with a neutral stimulus (SN), and the number of responses on the previous cocaine-paired lever was not reinstated. In the reinstatement test, responses to the cocaine-paired cues increased in the presence of the SD. Cebranopadol at the dose of 50 μg/kg significantly reduced relapse that was elicited by presentation of the SD. The data are expressed as the mean ± S.E.M. number of responses on the cocaine active lever (A) and inactive lever (B); n = 10. ##P < 0.01, significantly different from extinction; ***P < 0.01, significantly different from vehicle-treated rats (0.0 μg/kg); $P < 0.05, significantly different from 25 μg/kg.

Article Snippet: Drugs Cebranopadol (Med Chem Express, Monmouth Junction, NJ) was dissolved in vehicle that consisted of 5% dimethylsulfoxide, 5% Emulphor (Solvay, Bruxelles, Belgium), and 90% distilled water.

Techniques: